From the beginning of the last century, several vaccines have been used to save millions of lives and to protect people from diseases, such as measles, polio, and whooping cough. They are some of the most powerful and cost effective public health interventions available today.
However, there are still a number of diseases, such as HIV/AIDS and malaria, which do not have an effective vaccine.
The Makerere University Walter Reed Project (MUWRP) is a non-profit partnership between Makerere University and MHRP. MHRP has been conducting HIV research in Uganda since 1998 and expanded its portfolio to include prevention, care and treatment activities in 2005 under the President’s Emergency Plan for AIDS Relief (PEPFAR). More recently, MUWRP expanded its portfolio to research into other communicable diseases of public health importance in Uganda.
NDA regulates issues related to safety, quality, efficacy, handling and use of Pharmaceutical and other medical products in research. Part IV, section 40 of the National Drug Policy and Authority Act 2000 Edition, Chapter 206 states that with respect to clinical trials:
(1) The authority may issue a certificate to any person for the purpose of carrying out clinical trials in respect of a drug that may be specified in the certificate.
(2) No person may carry out any clinical trial in respect of any drug unless he or she is in possession of a certificate issued under subsection (1).
At the end of 2006, an estimated 39.5 million people were living with HIV and 4.3 million became newly infected with the virus that yeari. Prevention must be greatly prioritized in the response to AIDS and efforts are being made to find new prevention technologies to bolster the package of already known effective prevention methods. Male circumcision is one of these new potential methods, along with vaginal microbicides, pre-exposure prophylaxis with antiretroviral medication, herpes suppressive therapy, cervical barrier methods and HIV vaccines.
The Uganda National Council for Science and Technology (UNCST) is a semi-autonomous government agency established in 1990 (CAP 209 of the Laws of Uganda) to develop and implement strategies for integrating science and technology (S&T) into the national development process, provide advice to the government of Uganda on policy matters necessary for advancing S&T and, oversee and coordinate research and development (R&D) activities in Uganda. The UNCST is incorporated under the Ministry of Finance, Planning and Economic Development.
The purpose of research is to generate or contribute to generalizable knowledge that could benefit present and future generations. In order to achieve this purpose, some people have to bear the burden of research. It is necessary to ensure that the people who bear this burden of research also benefit in some way or that their rights and welfare are not compromised during the course of research. Therefore, these National Guidelines for Research involving Humans as Research Participants have been formulated to provide a system in Uganda that facilitates the carrying out of important research without compromising the rights and welfare of individual research participants.
Drawing on lessons from the scale-up of HIV interventions over the last few years, WHO, as the UNAIDS cosponsor responsible for the health sector response to HIV/AIDS, has established priorities for its technical work and support to countries on the basis of the following five Strategic Directions, each of which represents a critical area where the health sector must invest if significant progress is to be made towards achieving universal access.